Background: The Central Virginia Health District within the Commonwealth of Virginia comprises Lynchburg City, Amherst, Appomattox, Campbell, and Bedford. Demographics vary widely within the district, particularly between the City of Lynchburg and its more rural counties.

Methods: COVID-19 cases were collected from the Virginia Electronic Disease Surveillance System (VEDSS) database during the Delta and Omicron variant waves from July 17, 2021 - November 13, 2021, and November 27, 2021 - March 26, 2022, respectively. These final data were cleaned utilizing Microsoft Excel 2016 © and spatially analyzed through ArcGIS Pro 2.9.2 ©.

Results: Heat maps were generated to depict disease incidence between census block groups. Due to Omicron's increased transmissibility compared to Delta, Omicron incidence surpassed Delta by approximately ten thousand cases (45%) and affected a larger number of census block groups. Nevertheless, both maps reveal overlapping block groups. High Omicron and Delta were found in rural localities, mostly comprised of white senior citizens and middle-aged adults with low vaccination uptake. High incidence was shown in an inner city block group of Lynchburg City. The demographics skew younger, with a primarily African American composition and a median household income of roughly $20,000 less per year than the rural communities.

Conclusion: Future outreach efforts can focus on these target areas based on these findings. Such efforts should include community-specific vaccination and COVID-19 mitigation messaging targeting an older, white, conservative population in the rural areas and a young, African American population in inner city Lynchburg.