Background: Previous studies demonstrated that self-compassion could buffer the negative effects of discrimination on mental health. Suppression is an emotional regulation strategy that has been linked to discrimination and can lead to poor mental health outcomes. The goal of this study is to examine whether suppression mediates the relationship between discrimination and depression and whether self-compassion moderates this indirect effect. Methodology: Preliminary data were obtained from The Heart of Detroit Study (THDS), an ongoing longitudinal study among middle-aged and older African American adults living in Detroit. Analyses were conducted on 315 participants who completed the Everyday Discrimination Scale (EDS), the Self-Compassion Scale (SCS), the Emotional Regulation Questionnaire (ERQ), and the short form of the Center for Epidemiological Studies Depression Scale (CESD). Results: Higher levels of self-compassion were associated with lower levels of depression, and higher levels of suppression were associated with higher levels of depression. No relationship emerged between perceived discrimination and depression. Self-compassion moderated neither the relationship between perceived discrimination and depression nor the relationship between discrimination and suppression. Conclusions: These preliminary findings indicate that suppression is associated with depression in our sample and that self-compassion does not moderate the discrimination-suppression link and the discrimination-depression link. These results should be considered with caution, given the limitations of our measure of discrimination and the preliminary nature of our data.