Background: Epilepsy self-management (ESM) helps people with epilepsy (PWE) control their seizure frequency, increase their self-confidence, and better cope with their disease. Despite advances in the field, web-based interventions for ESM are still limited. Web-based applications have the potential to build trust and improve patient-provider communication by combining the tailored approach of face-to-face clinical interventions with the scalability of public health interventions.

Purpose: To enhance the Management Information Decision Support Epilepsy Tool (MINDSET), a decision-support evidence-based program (EBP), into a web-based accessible program with built-in algorithms that provide recommendations on other CDC Managing Epilepsy Well (MEW) EBPs. New program enhancements will also evaluate social determinants of health to reduce health disparities via reduced healthcare costs and improved access to care.

Methods: A phased development involved: 1) content analysis to upgrade functional specifications of the original MINDSET program; 2) literature review to determine inclusion criteria for enrolling PWE into other MEW EBPs and triaging for social support services; 3) expert panel review; 4) software upgrades; and 4) formative in-clinic evaluation with HCPs.

Results: MINDSET 2.0 has been upgraded from its original Adobe AIR technology to common cross-platform web-based standards. MINDSET algorithms provide recommendations to other MEW-EBPs based on existing validated scales including the Neurological Disorders Depression Inventory in Epilepsy (NDDI-E) and the QoLIE-31 cognitive scale. The enhanced version of MINDSET also includes a social determinant inventory adapted from Health Leads as a cue to HCPs.

Conclusion: MINDSET 2.0 accommodates in-person and distance ESM screening and action planning with added features to assist HCP's decision-making on appropriate treatment and prioritization of social determinants. Recent usability and feasibility findings show a potential that MINDSET enhancements can have in improving trust and communication among patients and HCPs ultimately leading to improved seizure control and overall quality of life.