Abstract

Exploring the relationship between childhood revictimization and mood-related pathology: The potential moderation by resilience biomarkers npy and DHEA

Hannah Cukor1, Alyson Zalta, Ph.D.2 and Sarah Stevens, Ph.D. Candidate2
(1)4201 Social & Behavioral Sciences Gateway, Irvine, CA, (2)University of California, Irvine, Irvine, CA

APHA 2024 Annual Meeting and Expo

Childhood abuse is a known risk factor for mood-related pathology in adulthood, but the contribution of childhood revictimization (or repeated/prolonged exposure to physically or sexually abusive experiences) remains understudied. Additionally, little is currently known about the biological underpinnings of this relationship, including the role that biomarkers such as neuropeptide Y (NPY) and dehydroepiandrosterone (DHEA) which have shown to be protective in trauma-exposed populations, may play in the relationship. This study hypothesized that higher rates of exposure to childhood revictimization would be associated with greater levels of mood-related pathology in adulthood and that resilience biomarkers NPY and DHEA will be found to moderate this relationship such that the association will be stronger in those with lower levels of NPY and DHEA.

A secondary data analysis of baseline data from a randomized controlled trial (NCT02279290) was conducted for this study. An ethnically diverse urban sample (N = 54) with a history of childhood interpersonal trauma were recruited. Childhood revictimization was measured via a weighted variable created using reported exposures to childhood victimization (defined as physical or sexual violations) from interview data. Instances of childhood victimization were coded 1 if the event occurred once and 2 if the event occurred more than once, the totals were then summed to create a cumulative score. Mood-related pathology was measured via a composite variable created from standardized and averaged scores on measures assessing PTSD (PCL-5) and depression, anxiety, and stress symptomatology (DASS-21) scores.

Zero order Pearson’s correlations were run to examine the bivariate relationships between revictimization, NPY, and DHEA, and mood-related pathology, and were then run again as partial correlations controlling for age, gender, socioeconomic status (SES), race, and ethnicity. No significant correlations were found between mood-related pathology and revictimization, nor NPY or DHEA with revictimization or mood-related pathology even after adjusting for covariates.

As 74% of the sample reported multiple childhood traumas, implications for research include accounting for the type of childhood abuse as each may differentially impact the development of mood-related pathology in adulthood. Further research on the relationship between resilience markers and mood-related pathology and revictimization are warranted.

Basic medical science applied in public health Clinical medicine applied in public health Public health biology Social and behavioral sciences