Exposure to chemicals in plastics have been linked to harmful health impacts across the entire human life-span, with findings corroborated by major scientific institutions including the World Health Organization, United Nations Environment Programme, American Academy of Pediatrics and more. Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease. This presentation will describe estimates of chronic disease across the lifespan but especially in children due to plastic exposure, and identify US and global policy steps and opportunities.