Endotoxins are bacterial lipopolysaccharides that are potent inducers of pulmonary inflammation. They are suspected to play a role in the exacerbation of asthma. Assessment of exposures to endotoxins in U.S. households is being surveyed in a nationwide population-based area probability sample in order to characterize exposure risk factors for asthma. Samples were collected from five sites within 831 homes representing the national distribution of housing types, geographical regions, and socioeconomic groups. Extensive health, demographic and housing data were also collected. Endotoxin concentrations in extracts of vacuumed dust were assayed using the kinetic chromogenic Limulus amebocyte lysate assay. Analyses of a subset of samples from the 831 homes demonstrated geometric mean values ranging from 10 to 40 Endotoxin Units/mg for bedroom, living room, and kitchen floor; bedding; and living room upholstery. Statistical analyses based on weighted national estimates demonstrated that there were significant geographical differences in endotoxin levels. Furthermore, higher endotoxin levels were significantly associated with homes with poor temperature control, households that included children, households with annual incomes below $30,000, and homes having residents with doctor diagnosed asthma. Conclusion: These analyses based on an interim dataset suggest that endotoxin is an important risk factor to consider in studies of asthma and to target for asthma intervention efforts. Supported by: NIEHS P30 ES05605, NIEHS DIR, HUD/OHHLHC
Learning Objectives: N/A
Keywords: Asthma, Environmental Exposures
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.