3250.0: Monday, October 22, 2001 - 8:42 PM

Abstract #28035

Fourteen-year follow up of HIV infected women in Kigali, Rwanda: The effects of war and HIV disease

Jareen Meinzen-Derr, MPH1, Susan A. Allen, MD, MPH, DTMH2, Etiene Karita2, Janna Bakari, MPH2, and William B. Fuller2. (1) Center for Pediatric Research, Eastern Virginia Medical School, 855 W. Brambleton Ave, Norfolk, VA 23510, 757-668-6414, meinzejk@chkd.com, (2) Dept. of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294

Background: The majority of HIV infected adults live in Africa, and 30% of adults residing in Kigali, the capital of Rwanda, are HIV positive(+). Between April and August 1994, a genocide took place in Rwanda; of 7.5 million Rwandan civilians, over 1 million died. Methods: Four hundred one women HIV(+) since 1986 were recruited from pediatric and prenatal clinics in Kigali, Rwanda, and were seen every 6 months prior to war and every 3 months post-war. Causes of death are drawn from medical charts and interviews with family and caretakers. The Kigali staging system is used to describe the stage of HIV disease. Results: By March 1994, 125 women had died, 105 due to AIDS related illness. From April-August 1994, 75 women died or disappeared during the war. Between September 1994-2000, 75 women died, 65 due to AIDS related illness. As of September 2000, 85 remain alive, 63 in HIV stages 1-2 and 22 in stages 3-4. Forty-one women have been lost to follow up. AIDS related deaths due to nonspecific illness such as diarrhea, wasting, enteritis increased from 31% before the war to 41% after the war (p=.036). Deaths due to tuberculosis increased from 13%- 26% (p=.034). Deaths due to Kaposi’s sarcoma, cryptococcal meningitis, esophageal candida decreased from 17%-5% (p=.02). Conclusion: The overall destruction of infrastructure caused by civil strife meant a lack of available treatment and decline in sanitation, leaving HIV-infected people more susceptible to gastroenteritis and TB.

Learning Objectives: N/A

Keywords: HIV/AIDS, Third World

Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.

The 129th Annual Meeting of APHA