Nearly 25% of all US women with AIDS have been diagnosed in New York City (NYC) where the proportion of AIDS cases in women increased from 8% in 1981 to 30% in 1997. In 1993 CDC added invasive cervical cancer (ICC) to the AIDS case definition. To determine the annual incidence of ICC in women with AIDS in NYC from 1987-97, HIV-infected women with ICC were identified by AIDS case surveillance and a review of the New York State (NYS) computerized hospital discharge summary. Diagnoses were confirmed by medical record review. The number of ICC cases expected for women 25-49 living with AIDS for the observed to expected standardized incidence ratio (SIR) was calculated by applying age and race specific NYC cervical cancer rates from the NYS Cancer Registry to the age and race specific estimates of the number of NYC women living with AIDS each year. Overall, 140 ICC cases were confirmed. Annual incidence of ICC per 100,000 women with AIDS rose from 140 in 1987 to a peak of 900 in 1990 and declined steadily to 102 in 1997. Average annual ICC SIR for 1987-91 was 36.2 (95% CI 26.7-47.7) declining in 1992-97 to 10.6 (95% CI 8.4-13.1). These data provide additional evidence for an elevated incidence of ICC in women with AIDS in the period 1987-97. One possible explanation for the recent decline in ICC incidence is that early detection and treatment of pre-invasive lesions is stopping development of ICC, the only potentially preventable AIDS-defining cancer.
Learning Objectives: The importance of screening for cervical cancer in HIV-infected women will be discussed
Keywords: HIV/AIDS, Cervical Cancer
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.