Assessing potential chronic sequelae of waterborne infections is a critical part of microbial risk assessments and formulation of public policy. A study was initiated to investigate the conceptual and evidentiary basis for association of chronic sequelae and waterborne pathogens. Definitions of chronic sequelae and human evidence for water-related chronic sequelae were examined. Public documents, scientific articles, medical and epidemiological dictionaries and texts, and citations from a report prepared for the Environmental Protection Agency (EPA) on chronic sequelae of waterborne pathogens were searched. Although the term is being used increasingly, it is frequently interpreted differently. For the purposes of reviewing the existing literature associating waterborne pathogens and long-term adverse health outcomes, we defined chronic sequelae as the secondary adverse health outcome that occurs as a result of a previous infection by a microbial pathogen, is clearly distinguishable from the illness that initially results from the causative infection, and lasts 3 months or more after recognition. As thus defined, chronic sequelae constitute a specific subset within a broader set of chronic conditions. In addition to the burden of chronic sequelae, economic and public health burdens arise from prolonged or unusually severe primary infections, as well as secondary complications that last over 3 months. A more systematic and scientific approach to defining and investigating the potential association between waterborne microbial pathogens and long-term health outcomes is needed.
Learning Objectives: At the conclusion of the session, the participant in this session will be able to 1) Identify different categories of long-term health outcomes following waterborne infections. 2) Discuss the implications of different definitions of chronic sequelae
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.