As an alternative to the 6-month regimen of isoniazid (INH), patients with latent tuberculosis infection (LTBI) attending the Nassau County public health clinics were placed on the newly recommended 2-month, 2-drug (rifampin and pyrazinamide) regimen for LTBI. In an 11 month period, 377 patients were placed on the regimen and 33% (123) completed therapy; 10% (38) stopped treatment due to adverse reactions, including nausea, indigestion, abdominal discomfort, rash and elevated liver enzymes. During prior 6-month periods, the completion of treatment rate for LTBI for patients receiving 6-month courses of INH ranged from 54% to 59%. Use of the new regimen has not led to higher completion rates.
Learning Objectives: Participants will be able to assess the effectiveness of treatment for latent tuberuculosis infection (LTBI); will be able to utilize the information to treat patients with LTBI; and will be able to develop more effective care plans for patients with LTBI
Keywords: Tuberculosis, Disease Prevention
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.