Research Objectives: To model the effects of medication non-adherence and medication regimen on health status, functioning, and quality of life outcomes for persons with schizophrenia enrolled in the U.S. Schizophrenia Care and Assessment Program (SCAP).
Study Design: Data were obtained from SCAP study participants who completed the baseline and the 6-month assessments and were using antipsychotic medications (n=530). Baseline characteristics and medications were used to predict 6-month outcomes using the SCAP Health Questionnaire (SCAP_HQ). Adherence at baseline and at six months reflected the 4-week period prior to each assessment. Health status (health score), functioning (social and daily activity), and quality of life (general life satisfaction) were modeled using ordinary least squares.
Principal Findings: No family history, undifferentiated type, private health insurance, and Medicare only were predictive of higher health scores. Being married and non-adherence at six months were predictive of lower health scores. College education and better health were predictors of higher social activities scores while persons on CHAMPUS exhibited lower scores. Better health, undifferentiated type, and summer birth were predictive of higher life satisfaction. Cohort (recently hospitalized) and non-adherence exhibited a negative impact on life satisfaction.
Conclusions: These findings suggest that prior period self-reported adherence may be predictive of subsequent period outcomes in health status and quality of life. Medication non-adherence is significantly associated with lower health status and lower life satisfaction and exhibits a negative (though, non-significant) impact on functioning outcomes.
Learning Objectives: To inform participants of the effects of medication non-adherence and type of medication used on health status, functioning, and quality of life outcomes for persons with schizophrenia
Keywords: Assessments, Health
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: Eli lilly & Company
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.