Back to Annual Meeting Page		American Public Health Association 133rd Annual Meeting & Exposition December 10-14, 2005 Philadelphia, PA

Abstract #101854

Tiffany Jones¹, Robin Taylor Wilson, MA, PhD², Lee E. Moore, PhD², and Demetrius Albanes, PhD². (1) Jackson Heart Study Undergraduate Training Center, Tougaloo College, 500 West County Line Road, JHSUTC, Tougaloo, MS 39174, 601-206-4006, jonestiffany21@yahoo.com, (2) Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd., Bethesda, MD 20892

Abstract

Background: Renal cell cancer is the 4th most rapidly increasing cancer in the United States. 50% of the cases are attributed to smoking, obesity, and hypertension.

Methods: Data was obtained from the Alpha-Tocopherol, Beta-Carotene Lung Cancer Prevention Study (ATBC). Men with renal cell carcinoma (245 cases and 28,888 controls) were identified through linkage to the Finnish Cancer Registry. Poisson's Rē statistic was used to investigate the linear correlation between smoking, body mass index, and diastolic blood pressure. Proportional hazard regression analysis was used to determine risk associated with renal cell cancer in multivariate models with adjustments for age, body mass index, pack years of smoking, and diastolic blood pressure.

Results: As compared with the controls within the ATBC study, the cases were slightly older and heavier smokers. Both cases and controls participated in moderate physical activity during their leisure time. Although in the majority of the cases and controls systolic blood pressure was found in the 50% percentile, the majority of cases had a higher diastolic blood pressure than the controls.

Conclusions: Higher body mass index and higher diastolic blood pressure were associated with the risk of renal cell carcinoma. Vitamin D intake, history of renal failure, and a history of diabetes were not associated with risks of renal failure.

Learning Objectives:

• To solidify (with statistical data)the 50% of known risk factors for renal cell carcinoma and to attempt to "discover" the unknown 50%.

Presenting author's disclosure statement:

I wish to disclose that I have NO financial interests or other relationship with the manufactures of commercial products, suppliers of commercial services or commercial supporters.