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APHA Scientific Session and Event Listing

Recorded presentation

Charles E. Rose Jr., PhD, Daniel C. Payne, PhD, Aaron Aranas, MPH, Michael M. McNeil, MD, and Susan Duderstadt, MD. Bacterial Vaccine-Preventable Disease Branch, Epidemiology and Surveillance Division, National Immunization Program, CDC, 1600 Clifton Rd NE, Mailstop C-09, Atlanta, GA 30333, 404-639-3028, cvr7@cdc.gov

Few large epidemiological studies have assessed if the receipt of multiple near-concurrent (MNC) vaccinations among adults is associated with adverse health outcomes. Our purpose is to investigate if the receipt of MNC vaccinations is associated with an increased risk of hospitalization among U.S. military personnel. Here we define a MNC vaccinations exposure as greater than or equal to 2 vaccinations during a two-day period. Data were obtained using the Defense Medical Surveillance System (DMSS), from January 1, 1998 through December 31, 2003. Using a case-crossover cohort method we compared the risk of hospitalization during a 120-day pre-exposure period to a 120-day post-exposure period. We included a 60-day wash-out period immediately preceding the MNC vaccinations exposure during which hospitalizations were excluded. Our data contains 117,885 active duty U.S. military personnel who were not deployed within the study period. There were 1,732 and 1,761 hospitalizations in the pre-MNC and post-MNC vaccinations exposure intervals, respectively. We used a Cox proportional hazards model to estimate the risk ratio (RR) and controlled for demographic, occupational, previous health care utilization, and calendar year. Receipt of greater than or equal to 2 MNC vaccinations was not significantly associated with the risk of hospitalization for the post- versus pre-exposure periods (RR = 0.90, 95% CI [0.74, 1.10]). Furthermore, no dose-dependent significant associations were detected for 2 only, 3 only, 4 only, or greater than or equal to 5 MNC vaccinations. Our results suggest that multiple vaccination practices in the U.S. military do not result in increased hospitalizations.

Learning Objectives: At the conclusion of the session, the participant (learner) in this session will

• Obtain information on the receipt of near-concurrent vaccines and risk of hospitalization for military personnel.
• be able to articulate a method for assessing the risk of short-term hospitalization after multiple near-concurrent vaccination.
• be able to develop a stategy for assesing the risk of adverse health outcomes and receipt of multiple near-concurrent vaccination.

Keywords: Epidemiology,

Presenting author's disclosure statement:

Any relevant financial relationships? No

Recorded presentation