181594 Associations between dietary heterocyclic amines and polycyclic aromatic hydrocarbons and colon cancer risk

Monday, October 27, 2008: 9:35 AM

Kassandra Auker , Department of Epidemiology/Biostatistics, Department of Family Medicine, Case Western Reserve University, Cleveland, OH
Cheryl Thompson, MS, PhD , Department of Family Medicine, Case Western Reserve University, Cleveland, OH
Nathan A. Berger, MD , Department of Medicine, Case Western Reserve University, Cleveland, OH
Thomas Tucker, MD, MPH , Kentucky Cancer Registry, University of Kentucky, Cleveland, OH
Li Li, MD, PhD , Department of Epidemiology and Biostatistics, Department of Family Medicine, Case Western Reserve University, Cleveland, OH
Meat intake, red meat in particular, is a recognized risk factor for colon cancer. Heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs), produced when meats are cooked at high temperatures, are believed to be important colon carcinogens, and have been associated with increased risks of colon cancer in some, but not all, epidemiologic studies. We sought to further clarify this relationship in a Kentucky SEER Cancer Registry-based incident case-control study. Dietary data were collected from 1,296 participants (524 cases, and 772 population controls) using the validated Arizona Meat Preparation Questionnaire. This 50-item self-administered instrument measures intakes of 2-Amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), 1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine (PhIP), 2-amino-3,4-8-trimethyl-imidazo[4,5-f] quinoxaline (DiMeIQx), and Benzo() pyrene (BaP) based on participants' responses to frequency of meat consumption and its relative doneness. Using a two-sided t-test, we found that MeIQx (p = 0.011) and DiMeIQx (p = 0.029) were statistically different between the cases and controls whereas PhIP (p = 0.493) and Benzo() pyrene (p = 0.464) were not statistically significant. Multivariate regression analysis of the relative risk (odds ratio) for HCAs and PAHs is forthcoming. These data add evidence supporting that meat intake, MeIQx and DiMeIQx in particular, may promote colon carcinogenesis.

Learning Objectives:
Identify the risk of colon cancer associated with dietary consumption of heterocyclic amines and polycyclic aaromatic hydrocarbons.

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have conducted all analyses presented in this abstract
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

See more of: Cancer Epidemiology
See more of: Epidemiology