198288 Diabetes, Hyperglycemia, and Decreased Glomerular Filtration Rate in A Taiwanese Metropolitan Adult Population

Wednesday, November 11, 2009: 9:35 AM

Cheng-Chieh Lin , Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
Tsai-Chung Li , Graduate Institute of Biostatistics, China Medical University, Taichung, Taiwan
Chiu-Shong Liu , Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
Chia-Ing Li , Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
     
Objective: The objective of this study was to assess the association of renal function estimated by glomerular filtration rate with hyperglycemia (impaired fasting glucose [IFG]) and diabetes in a Taiwanese metropolitan adult general population.

Methods: We did a cross-sectional survey in a representative random sample of 2,350 Taiwanese adults aged 40 years and over who lived in a metropolitan city, Taiwan in 2004-05. Renal function was assessed with estimated glomerular filtration rate (GFR) using the modified Modification of Diet in Renal Disease (MDRD) Study equation.

Results: Of the participants, 593 (25.23%) had IFG and 287(12.21%) had diabetes. The GFR level was significantly lower among diabetic participants (-4.70 mL/min/1.73 m2 compared to individuals with normal glycemia, p< 0.001) and those with IFG (-6.62 mL/min/1.73 m2 compared to individuals with normal glycemia, p< 0.001). After adjusting for age, gender, smoking, alcohol drinking, central obesity, BMI, percent body mass fat, and components of metabolic syndrome, IFG was associated with an OR of 1.51 (95% confidence interval: 1.04, 2.18) and diabetes was associated with an OR of 2.43 (95% confidence interval: 1.62, 3.64) for stage 3 or higher of kidney function (GFR< 60 mL/min/1.73 m2).

Conclusions: Our findings show that dysglycemia is associated with decreased renal function estimated by GFR. This association is consistent in diabetic individuals, and also extends to those with IFG.

Learning Objectives:
The objective of this study was to assess the association of renal function estimated by glomerular filtration rate with hyperglycemia (impaired fasting glucose [IFG]) and diabetes in a Taiwanese metropolitan adult general population.

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I designed, planned and coordinated the study. I will present its result in APHA.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

See more of: Diabetes Epidemiology
See more of: Epidemiology