212533 Surveillance of Antibiotics use and Prevalence of their resistance in Orthopedic Department, Egypt

Sunday, November 8, 2009

Azza Mahmoud Hassan, PhD, MD , Microbiology and Immunology Department, Tanta University, Egypt, Mahalla, Egypt
Omaima I. Abo-El-Kheir, PhD, MD , Faculty of Medicine, Public Health department, Alazhar University, Cairo, Egypt
Magdy El Guinaidy, MD , Gastroenterology and Hepatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Background: Antimicrobial use and subsequently antimicrobial resistance among bacterial pathogens is a global problem, but in Egypt data are sparse. Orthopedic departments reflect this problem because in them surgery constitutes the main manipulation and septic diseases constitute common complications both need guided antimicrobial therapy otherwise antimicrobial resistance will emerge.

Methods: A prospective study on antimicrobial use and the antimicrobial susceptibility patterns of the isolated organisms in Orthopedic Department, Tanta University Hospital, Egypt, within 9 months was carried out.

Results: High antimicrobial prescription rates (98.1%) with low rates of appropriateness (11.3%) were detected. Eighty-one percent of prescribed antimicrobial agents belong to cephalosporins and penicillins classes Antibiotics were given for prophylaxis continued post-operatively (77%), for infections (13.4%) as well as randomly (22%). High rates of resistance were found in most of the bacteria studied. 53.3% of Staphylococcus aureus (S. aureus) and 66.7% of coagulase-negative staphylococcus (CNS) isolates were oxacillin resistant. Multi-resistant (MR) strains represented 48.6% of the isolated gram negative strains of which 29.2% were ESBL (Klebsiella 62.5% and E.coli 33.3%) while 19.4% were MR Pseudomonas and Acinetobacter isolates.

Conclusion: Antibiotic treatment in our Orthopedic Department appears to be substantial. Increasing and justifying efforts are needed to improve appropriateness of antimicrobial therapy, minimize the development of antimicrobial resistance, and improve clinical and financial results. These results also call for a nationwide surveillance programme to monitor microbial trends and antimicrobial resistance patterns in Egypt.

Learning Objectives:
The present study was undertaken to define the pattern of antibiotics use, identify the infecting micro-organisms, determine the resistance patterns among the isolated bacteria and identify multi-resistant bacteria from different isolates, in Orthopedic Department, aiming to highlight the present situation and the urgent need to design an antibiotic policy as a part of efficient infection control measures in our hospitals.

Keywords: Data/Surveillance, Antibiotic Resistance

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: - Ph.D.,MD Public health - Lecturer of public health at faculty of medicine, Alazhar university, Egypt
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.