4271.0 Opportunities and obstacles with Genome Wide Association Studies (GWAS)

Tuesday, November 9, 2010: 2:30 PM - 4:00 PM
Oral
We propose to host a 90-minute symposium to provide a basic overview of GWAS and discuss the opportunities and obstacles of using these techniques. Researchers will share their experiences and explore approaches to examining the patterns of genetic variation in diverse populations. This proposed symposium will: 1) provide a general overview of GWAS and the context to which these studies are used in the field; 2) discuss methodologic approaches that have been used and share some results from these efforts; 3) discuss opportunities and obstacles in analyzing GWAS; 4) discuss implications of these methods to public health; and 5) provide an opportunity for the panel presenters to interact with the audience through a question-and-answer session.
Session Objectives: 1. Describe the Genome-wide Association Study (GWAS) design including the opportunities and challenges associated with this popular method. 2. Identify the strengths and limitations of GWAS 3. Name resources to facilitate a) generalizing GWAS-identified associations to diverse populations (PAGE - www.pagestudy.org); and b) the conduct of cross-study analyses (PhenX - www.phenxtoolkit.org).
Organizers:
Diane Wagner, PhD and Erin Ramos, PhD, MPH
Moderators:
Erin Ramos, PhD, MPH and Diane Wagner, PhD

3:00pm
Analysis of GWAS: Opportunities and Obstacles
Sara Lindstrom, PhD and Peter Kraft, PhD
3:15pm
Population Architecture using Genomics and Epidemiology (PAGE) -- from SNPs to GWAS and Beyond
Dana Crawford, PhD, Gerardo Heiss, MD, PhD, Charles Kooperberg, PhD, Loic Le Marchand, MD, PhD, Tara Matise, PhD, Josť Luis Ambite, PhD, Steven Buyske, PhD, Shelley Cole, PhD, Christopher Haiman, ScD, Teri Manolio, MD, PhD, Kari North, PhD, Ulrike (Riki) Peters, PhD, MPH, Marylyn Ritchie, PhD, Lucia Hindorff, PhD, MPH, Jonathan Haines, PhD and . The PAGE Study
3:30pm
Public health implications of the use of standard epidemiologic measures: The PhenX Toolkit
Diane Wagener, PhD, Richard K. Kwok, PhD, Dean Jackman, PMP, Michal Zmuda, Wayne Huggins, PhD, Amanda Flynn, Ying Qin, MS, Vesselina Bakalov, MS, Helen Pan, PhD, Destiney Nettles, Joseph Pratt, MPM, Deborah Maiese, MPA, Lisa C. Strader, MPH and Carol M. Hamilton, PhD
Panel Discussion

See individual abstracts for presenting author's disclosure statement and author's information.

Organized by: Epidemiology
Endorsed by: Genomics Forum

CE Credits: Medical (CME), Health Education (CHES), Nursing (CNE), Public Health (CPH)

See more of: Epidemiology