256600 Toxic Metal Exposures and C-Reactive Protein among US non-smoking adults: NHANES 1999-2010

Tuesday, October 30, 2012

Juhua Luo, PhD , Department of Community Medicine, West Virginia University, Morgantown, WV
Yixia Li , Department of Community Medicine, West Virginia University, Morgantown
Michael Hendryx, PhD , West Virginia Rural Health Research Center, West Virginia University, Morgantown, WV
Few studies on environmental metal exposures have been conducted among non-smokers, and few have examined interaction effects from exposure to more than one metal. The objectives of this study were 1) to test the hypothesis that metal exposure (including barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, and tungsten) would be associated with the inflammatory marker C-reactive protein (CRP) among non-smoking adults aged 19 or older, and 2) to explore interaction effects among these metals. We used data from the National Health and Nutrition Examination Survey (NHANES) 1999-2010. The dependent variable was a clinically raised CRP level >1.00 mg/dl. Among 4,738 non-smoking adults, urinary cadmium and antimony were associated with elevated CRP in a dose-dependent fashion (p for trend <0.001 for both metals) adjusting for age, gender, race and obesity. The adjusted odds ratio for elevated CRP comparing the fourth quartile to the first quartile of the cadmium distribution was 1.92 (95% confidence interval [CI], 1.17-2.53); that for antimony was 1.72 (95% CI 1.17-2.53). The adjusted odds ratio for elevated CRP was significant in the third quartile of tungsten and remained marginally but non-significantly increased for the fourth quartile compared with the first quartile. Elevated CRP was not associated with other selected metals. We did not find evidence that interactions among pairs of metals increased risk of elevated CRP. Environmental exposures to cadmium, antimony and tungsten that are not confounded by personal smoking behavior seem to promote an inflammatory response.

Learning Areas:
Environmental health sciences
Public health or related research

Learning Objectives:
Evaluate environmental exposures to toxic metals in relation to c-reactive protein

Keywords: Environmental Exposures, Environmental Health

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am an assistant professor focusing on the epidemiology of cancer and enviromental exposures. My research interests include tobacco prevention, environmental epidemiology and cancer epidemiology.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.