266335 Incidence of Multiple Primary Cancer in Taiwan - A population-based cancer registration Study

Tuesday, October 30, 2012

Ho-Min Chen , Center of Comparative Effectiveness Research, National Taiwan University Hospital, Taipei City, 100, Taiwan
Wen-Yi Shau , Division of Health Technology Assessment, Center For Drug Evaluation, Taipei, Taiwan
Zhong-Zhe Lin , Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
Yu-Yun Shao , Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
Raymond Kuo, PhD , Center of Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei City, Taiwan
Mei-Shu Lai, MD, PhD , Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei City, Taiwan
Introduction: The advances in cancer diagnosis and treatment have allowed for more effective cancer care and prolonged patient survival. However, clinical oncologists are also aware of the increased incidence of multiple primary cancers (MPC) followinga patient's first cancer. Due to genetic susceptibility, carcinogenic exposure, and treatment effects, patients who have been diagnosed with cancer are more likely to develop MPC in their lifetime. The present study analyzed the relative risk of developing MPC for the top 10 leading cancers in Taiwan.

Method: All newly diagnosed cases of invasive cancer belonging to the top 10 leading cancers and reported to the Taiwan Cancer Registry database between 1996 and 2005 were selected for this study. MPC was defined as a separate diagnosis of independent cancer two months after the first cancer was diagnosed. The standardized incidence ratio (SIR) was calculated as the number of MPC observed divided by the expected number of general population for each 5-year period, adjusted by age and gender.

Result: A total of 223635 male and 173649 female patients were included. They had been followed for 735119 and 840613 person years during which 11781 (5.3%) and 6294 (3.6%) MPCs were diagnosed, respectively. Most cancers had a significantly high SIR (ranging from 1.10-4.42), except Stomach for women and liver, lung and prostate for men. Elevated SIRs were found for Oral cavity, Esophagus, Nasopharynx and Lung cancers for male patients, and Breast, Corpus Uteri and Ovary cancers for female patients.

Conclusion: For some specific primary cancers, continuous medical management is required following the initial treatment.

Learning Areas:
Public health or related research

Learning Objectives:
List the association between first primary and following cancers in Taiwan

Keywords: Cancer, Taiwan Health

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am the principal inspector of the supporting research project and also one the author who prepared the draft. The submission of this abstract and acting as the presenter is agreed by all other co-authors.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.