268094 Secular trend analysis for cervical cancer incidence during 1991-2008 in Taiwan

Tuesday, October 30, 2012

Huang-Cheng Hsu , Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan
Yun-Yuan Chen , Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan
Shu-Chun Hsiao , Cancer Control and Prevention Division, Bureau of Health Promotion, Department of Health, Taipei, Taiwan
San-Lin You , National Taiwan University.Taipei.Taiwan, College of Public Health, Taipei, Taiwan
Yih-Shyan Chen , Cancer Control and Prevention, Bureau of Health Promotion, Department of Health, R.O.C. (Taiwan), Taipei, Taiwan
Shin-Lan Koong , Department of Cancer Prevention, the Bureau of Health Promotion, Department of Health, Taiwan, Taipei, Taiwan
Chi-An Chen , National Taiwan University Hospital, Department of Obsterics and agaynecology, Tapei, Taiwan
Chien-Jen Chen , Academia Sinica, Genomic Research Center, Taipei, Taiwan
Cervical cancer screening in Taiwan has been implemented since 1995. For evaluation of efficacy, the study aimed to observe the secular incidence trend during 1991-2008 of cervical squamous cell carcinoma(SCC) and adenocarcinoma(ADC), and to build models to found factors influenced the secular change.

The age, education, and residence specific women numbers aged >=30 years were collected from Taiwan demographic fact book. Cancer cases were ascertained from Taiwan Cancer Registry Database. Age-standardized incidences of squamous cell carcinoma and adenocarcinoma were calculated and used joint point regression to find out suitable numbers of joint points. Poisson regressions were used to evaluate the factors associated with the secular changes.

The turning points of SCC and ADC incidence trends were located at 1998 and 2000, incidence before turning point were annually increased 1.04% and 4.38%, and incidence after that were annually decreased 9.05% and 4.52%, respectively. Compared with 30-34 year old women, SCC incidence was increased with age and peaked at aged 65+ (RR=7.5, 95%CI:7.1-8.0), and ADC incidence was peaked at aged 45-49 women (RR=4.7, 95%CI:4.0-5.5). Both SCC and ADC incidence was highest in central Taiwan, and women attended school <6 years possess the highest risk of developing both SCC and ADC.

The secular trend is highly correlated with the ongoing screening program. The decreased incidence was mainly explained by calendar year, and increased age, decreased schooling years and specific residences were correlated with increased incidence. The factors found in Poisson regression may provide improved strategy and hence need to be further evaluated in the future.

Learning Areas:

Learning Objectives:
To evaluate the secular trend of cervical cancer incidence.

Keywords: Cervical Cancer, Screening

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am working at cervical cancer screening task force in Taiwan and in incharge of data analysis and interpretation.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.