142nd APHA Annual Meeting and Exposition

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297440
Cholesterol and mortality a study from China

142nd APHA Annual Meeting and Exposition (November 15 - November 19, 2014): http://www.apha.org/events-and-meetings/annual
Tuesday, November 18, 2014 : 1:15 PM - 1:30 PM

Wenjie Sun , Tulane University, New Orleans, LA
Objective: To investigate the association between total cholesterol and mortality and examined whether the association varied by health status in elderly Chinese

Methods: We used multivariable Cox regression to examine the adjusted total cholesterol with all-cause mortality by health status in a population-based cohort study of all 80,088 enrollees, aged 65 years or above, from July 2008 to December 2010 at all 52 Comunitiy health Centers of Guangdong, China.

Results: After a mean follow-up of 3.0 years, there were 5,355 deaths in  participants with complete information. Cholesterol was significantly positive associated with the CHD mortality (HR= 1.12, 95%CI 1.04-1.21), but negative associated with all-cause (HR=0.91 95%CI 0.89-0.94) and non-CVD mortality, such as cancer and respiratory disease mortality. The association of total cholesterol with all-cause mortality varied by baseline health status (5 categories) (P=0.01). Higher cholesterol associated with significant decreased all-cause mortality in the unhealthy but not health people.

Conclusions: The cholesterol-death association was positive for coronary heart disease but not other cardiovascular diseases, and inverse for cancer, respiratory diseases in both sexes. It appeared to benefit mainly older people in poor health. The harmful effect of cholesterol on mortality may have been over-estimated in elderly people because of reverse causality. Lower TC might not an independent risk factor for increased mortality, but a mark in Chinese older people

Keywords: Cholesterol; elderly; mortality; reverse causality

Learning Areas:

Epidemiology

Learning Objectives:
Discuss the relationship between cholesterol and mortality

Keyword(s): Aging, Chronic Disease Prevention

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have been the principal or co-principal of multiple federally funded grants focusing on the epidemiology of the project.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

Back to: 4223.0: Chronic Disease Epidemiology