142nd APHA Annual Meeting and Exposition

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Serum retinol-binding protein 4 linked adolescent cardiometabolic risk components to metabolic syndrome and insulin resistance

142nd APHA Annual Meeting and Exposition (November 15 - November 19, 2014): http://www.apha.org/events-and-meetings/annual
Sunday, November 16, 2014

Wei-Ting Lin , Institute of Environmental and Occupational Health Sciences, National Yang-Ming University, Taipei, Taiwan
Te-Fu Chan , Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
Hsiao-Ling Huang , Kaohsiung Medical University, Kaohsiung, Taiwan
Meng-Hsueh Chen , Kaohsiung Medical University, Kaohsiung, Taiwan
Chun-Ying Lee , Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
Yu-Wen Chiu, DrPH , School of Public Health, Louisiana State University Health Sciences Center - New Orleans, New Orleans, LA
Chien-Hung Lee , Kaohsiung Medical University, Kaohsiung, Taiwan
Background: Cardiometabolic risk factors can be exhibited by children and may persist into adulthood. RBP4 has been related to sugar-sweetened beverage consumption, and proposed to be a vital mediator connecting obesity and insulin resistance (IR).

Objectives: This study investigated the role of RBP4 in the adolescent by evaluating the association of its serum levels with cardiometabolic risk components and outcomes.

Methods: A total of 272 representative adolescents were randomly selected from a large-scale cross-sectional study. Data were analyzed using principal component analysis and multivariate regression models adjusted for covariates. 

Results: Three principal components were extracted from 12 cardiometabolic risk factors and the first principal component (PC1) explained 38.7% of the total variance. RBP4 levels were positively correlated to body-weight-related parameters, triglyceride, systolic blood pressure and uric acid in both sexes and to metabolic syndrome (MetS) and IR. Significant multivariate-adjusted differences at RBP4 levels (1.999 ng/dl in boys and 2.377 ng/dl in girls) for a one-unit increase in PC1 scores were found among adolescents with hyperuricemia, but not among those without. Circulating RBP4 levels were notably capable at discriminating the presence of MetS and IR. A one-standard deviation increment of RBP4 was associated with a 2.5- and 1.9-fold risk of contracting MetS and IR, respectively, and explained 5.5% and 13.7% of the excess risk of PC1 on these two metabolic disorders.

Conclusions: Circulating RBP4 levels are associated with combined-cardiometabolic risk components and adolescent MetS and IR. Hyperuricemia demonstrates clinical implications on the positive correlation between continuous cardiometabolic risk-scores and RBP4 levels.

Learning Areas:

Chronic disease management and prevention
Other professions or practice related to public health
Public health or related research

Learning Objectives:
Demonstrate the role of serum retinol-binding protein 4 levels on cardiometabolic risk components and outcomes.

Keyword(s): Adolescents, Children and Adolescents

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: In this study, I was responsible for participant recruitment, blood sample examination, data analysis and result interpretation. I also drafted this abstract. I am sure that I am qualified to be an abstract author. Furthermore, no competing interests exist in this study
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.