Breast cancer research priorities using occupational populations
Methods: In order to verify and examine evidence in support of a role for chemicals in plastics being causes and co-factors in breast cancer initiation, two study designs are proposed. The first makes use of the National Health and Nutrition Examination Survey (NHANES) conducted periodically by CDC which collects detailed demographic, reproductive and health outcomes as well as blood levels for specific classes of chemicals, including some present in plastics formulations such as flame retardants and plasticizers. The second design identifies a cohort of automotive plastics workers from historical records and performs a mortality follow-up to identify breast cancer deaths. If an excess is confirmed, a detailed retrospective exposure assessment and survey questionnaire on demographic and reproductive risk factors will be performed permitting examination of exposure associations.
Results: The results from the NHANES analysis will be presented. The automotive plastics worker cohort will be described, including available work history and historical plant process characterization.
Conclusions: The observations will be discussed in relation to the specific prior hypotheses linking breast cancer risk and exposures to carcinogens and endocrine disruptors. Implications for research in the current breast cancer epidemic and appropriate responses for the cancer research establishment will be discussed.
Learning Areas:Environmental health sciences
Occupational health and safety
Demonstrate knowledge of the current state of the science with regard to potential occupational etiologies of breast cancer
Keyword(s): Cancer and Women’s Health, Epidemiology
Qualified on the content I am responsible for because: I am the primary researcher on the project presented.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.