142nd APHA Annual Meeting and Exposition

Annual Meeting Recordings are now available for purchase

Breast cancer research priorities using occupational populations

142nd APHA Annual Meeting and Exposition (November 15 - November 19, 2014): http://www.apha.org/events-and-meetings/annual
Tuesday, November 18, 2014 : 4:50 PM - 5:10 PM

Robert Park, MS , Risk Evaluation Branch, National Institute for Occupational Safety and Health, Cincinnati, OH
Background and Objectives: Endocrine disrupting chemicals and carcinogens in occupational environments may cause breast cancer. A large case-control study identified automotive plastics workers as having substantially elevated breast cancer risk, and proposed testable hypotheses on causation.

Methods: In order to verify and examine evidence in support of a role for chemicals in plastics being causes and co-factors in breast cancer initiation, two study designs are proposed. The first makes use of the National Health and Nutrition Examination Survey (NHANES) conducted periodically by CDC which collects detailed demographic, reproductive and health outcomes as well as blood levels for specific classes of chemicals, including some present in plastics formulations such as flame retardants and plasticizers. The second design identifies a cohort of automotive plastics workers from historical records and performs a mortality follow-up to identify breast cancer deaths. If an excess is confirmed, a detailed retrospective exposure assessment and survey questionnaire on demographic and reproductive risk factors will be performed permitting examination of exposure associations.

Results: The results from the NHANES analysis will be presented. The automotive plastics worker cohort will be described, including available work history and historical plant process characterization.

Conclusions: The observations will be discussed in relation to the specific prior  hypotheses linking breast cancer risk and exposures to carcinogens and endocrine disruptors. Implications for research in the current breast cancer epidemic and appropriate responses for the cancer research establishment will be discussed.

Learning Areas:

Environmental health sciences
Occupational health and safety

Learning Objectives:
Demonstrate knowledge of the current state of the science with regard to potential occupational etiologies of breast cancer

Keyword(s): Cancer and Women’s Health, Epidemiology

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am the primary researcher on the project presented.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.