142nd APHA Annual Meeting and Exposition

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High degree of interest in long-acting injectable pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) in two Chinese cities

142nd APHA Annual Meeting and Exposition (November 15 - November 19, 2014): http://www.apha.org/events-and-meetings/annual
Monday, November 17, 2014 : 10:54 AM - 11:09 AM

Kathrine Meyers, DrPH MPP , Aaron Diamond AIDS Research Center, New York, NY
Elwin Wu, PhD, MS , Columbia University School of Social Work, New York, NY
Haoyu Qian, MPH , Aaron Diamond AIDS Research Center, New York, NY
Xiaojie Huang, MD , Infectious Disease Department, Beijing You’an Hospital,Capital Medical University, Beijing, China
Hao Wu, MD , Infectious Disease Department, Beijing You’an Hospital,Capital Medical University, Beijing, China
Background: Long-acting injectable (LAI) formulations of pre-exposure prophylaxis (PrEP) represent the next generation of HIV prevention since they could circumvent the adherence challenges associated with daily Truvada. To strengthen planned efficacy trials, including those with at-risk populations in China, this study measured interest in a LAI formulation requiring an intramuscular injection every twelve weeks among MSM in two cities with annual incidence rates among MSM >5%.

Methods: From September to December 2013, 170 MSM in Beijing (n=99) and Shenyang (n=71) completed a computer-based survey collecting self-reported data on willingness to take LAI-PrEP (the primary variable of interest) as well as sociodemographics and sexual risk.

Results: Three-quarters of the cohort (75.3%) expressed willingness to use LAI-PrEP; those willing were significantly older than those not (mean age 32.4 vs. 29.3, p=.04). Level of education was significantly associated with willingness to use LAI-PrEP (c2=10.3, df=3, p=.02), ranging from 85.0% among those with middle school education or less to 53.3% among those with graduate degrees. At each stratum of sexual risk level, a majority indicated willingness to use LAI-PrEP. Notably, 91.7% of those reporting unprotected receptive anal intercourse (URAI) over the past 3 months vs. 72.6% among those reporting no URAI (c2=4.03, df=1, p=.07) expressed willingness, suggesting that further study of willingness to use and potential promise of LAI-PrEP among those engaging in high risk sexual behavior is warranted.

Conclusion: LAI-PrEP could be a desirable prevention strategy for MSM in China, notably perhaps for those at elevated risk for sexually-transmitted HIV.

Learning Areas:

Planning of health education strategies, interventions, and programs
Provision of health care to the public
Public health or related research
Social and behavioral sciences

Learning Objectives:
Describe interest in long-acting injectable PrEP among MSM in China; identify sociodemographic and sexual risk factors associated with differences in acceptability of long-acting injectable PrEP.

Keyword(s): HIV Interventions, Clinical Trials

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have been principal or co-investigator of internally-funded research projects that focus on HIV prevention, including prevention of mother to child transmission and PrEP in the US and in China. My most recent work is in the development of strategies to recruit, enroll, and retain high risk MSM in HIV prevention research.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.