142nd APHA Annual Meeting and Exposition

Annual Meeting Recordings are now available for purchase

NIEHS Mouse Methylome Project: What We Can Learn from the Epigenomic Landscape

142nd APHA Annual Meeting and Exposition (November 15 - November 19, 2014): http://www.apha.org/events-and-meetings/annual
Tuesday, November 18, 2014 : 10:50 AM - 11:10 AM

Alex Merrick, PhD , National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC
The mouse is an important tool in molecular genetics which can be manipulated to study the relationship of genes and the epigenome for insights into human disease.  The NIEHS Mouse Methylome Project is a cross-disciplinary effort to completely map and organize DNA methylation in mouse liver.  We are using advanced next generation sequencing technologies, biocomputation, biostatistics and molecular biology to create a high-resolution map of the mouse liver 5’-methylcytosine genome from three different mouse strains with differential sensitivity to chemically-induced toxicity and disease.  The methylome, genome and transcriptome of paternal strains and F1 male and female offspring are being compared to answer questions on how the epigenomic landscape varies between strains and genders and also about epigenomic inheritance to offspring and differences among siblings.  Characterization of the mouse epigenome and gene expression in key tissues could provide an experimental means for investigating similar questions about epigenomic responsiveness to varying nutritional status and disease susceptibility.

Learning Areas:

Environmental health sciences

Learning Objectives:
Describe the NIEHS Mouse Methylome Project

Keyword(s): Environmental Health, Environmental Justice

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have been a principal investigator at the National Institute of Environmental Health Sciences for over 20 years and have published many papers on gene expression and genomics. My interests are environmental chemical exposure, genomics and public health.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.