Staten Island Breast Cancer Research Initiative: Length of residence on Staten Island, inter Island differences, puberty, and breast cancer mortality risk with respect to environmental contamination sites
Staten Island, NY (SI) is downwind from the largest petrochemical industry in the world, 40 EPA Superfund sites, (2 National Priority List [NPL], 9 Active and 29 Archived) and for more than 50 years harbored the largest open dump, Fresh Kills Landfill. Using breast cancer incidence and mortality data from New York State Department of Health (NYSDOH) and New York City Department of Health and Mental Hygiene (NYCDOHMH) respectively, it has been determined that SI has among the highest female breast cancer age-adjusted incidence and the highest age-adjusted mortality rate in the metropolitan region. Researchers at the Center for Environmental Science developed and validated a methodology for obtaining data from a combination of newspaper obituaries and death certificates. Death certificate data for breast cancer deaths were initially obtained for 1980-1990 and subsequently for 1991-2006 from NYCDOHMH as well as, a set of female controls for the same time periods. Life histories were compiled through obituary interviews for both cases and controls for the entire Island. Neighborhoods (n=61) were obtained for individuals who spent their puberty years on Staten Island, subsequently combined into community districts (CD) (n=3) and examined for inter-Island differences. Geographic Information System (GIS) was used to map all neighborhoods. Preliminary analysis using logistic regression demonstrated a statistically significant increase in the risk for breast cancer mortality:  when residing on SI during puberty (p<0.001), and  with length of residence on SI (p< 0.001). However, preliminary analysis using logistic regression demonstrated no statistically significant increase in the risk for breast cancer mortality associated with specific neighborhood/community district residence during puberty years (CD1= p<0.12, CD2= p<0.07, CD=3 p<0.80).
Environmental health sciences
Planning of health education strategies, interventions, and programs
Public health or related education
Public health or related research
Identify cancer risk factors for urban populations due to environmental perturbations
Discuss environmental health with respect to cancer
Keyword(s): Cancer, Environmental Health
Presenting author's disclosure statement:
Qualified on the content I am responsible for because: I have been the principal investigator of multiple New York City, New York State and privately funded grants focusing on the environmental epidemiology of breast cancer mortality risk and exposure to estrogenic compounds during puberty years. Among my scientific interests has been breast cancer education to underserved populations deserving environmental justice.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines,
and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed
in my presentation.